Establishing Causality for Complex Chemical Mixtures

For complex chemical mixtures, experimental techniques are frequently used to evaluate causality. Options include:

• Evaluating separated components of the mixture.
• Developing and testing a synthetic mixture.
• Determining how a mixture's toxicity relates to that of individual components.

The choice of method depends on the goal of the assessment and the resources that are available.

Relevant guidelines section(s): 4.3.1.2