| Approach |
Explanation |
| Define the lines of evidence early in the risk assessment. |
Lines of evidence should be defined during problem formulation
when developing the conceptual model and selecting assessment
endpoints. |
| Evaluate all available information, quantitative and
qualitative. |
Don't approach this process as a rigorous examination of weights
of evidence, where opposing factors are balanced based on assignment
of quantitative values to reach a conclusion about a "weight."
Instead, use a more inclusive approach: evaluate all available
information, even qualitative evidence. |
| Pursue multiple lines of evidence, where possible. |
You can increase confidence in the conclusions of a risk assessment
by using several lines of evidence to interpret and compare
risk estimates. These lines of evidence may be derived from
different sources or by different techniques relevant to adverse
effects on the assessment endpoints, such as quotient estimates,
modeling results, or field observational studies. |
General Rules to Follow When Evaluating Lines of Evidence (Text Version)