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After you estimate the changes to assessment endpoints and evaluate
lines of evidence, the next step is to determine whether the changes
are adverse and evaluate the degree of adversity. Risk assessors
often rely on their professional judgment.
There are three criteria for evaluating adverse changes in assessment endpoints:
- Nature and intensity of effects.
- Spatial and temporal scale.
- Potential for recovery.
Let's look at each of these in turn.
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Extent of the Evaluation
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Relevant
guidelines section(s): 5.2.2
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